Zhonghua wai ke za zhi [Chinese journal of surgery]
-
Zhonghua Wai Ke Za Zhi · Apr 1992
Randomized Controlled Trial Clinical Trial[Clinical study of prophylactic use of gentamicin and metronidazole in the surgery of colorectal carcinoma].
From Oct. 1989 to Apr. 1990, 16 patients with colorectal carcinoma undergoing elective radical resection were randomly divided into two groups to receive oral and combined (oral + i.v.) antimicrobials respectively. Patients in the oral group received preoperative oral gentamicin and metronidazole for two days, in the combined group oral medication was followed by the same antimicrobials intravenously during perioperative period. Quantitative bacterial cultures were performed before and after the regimen. ⋯ In the oral group, effective concentration of metronidazole were found in serum and tissues but gentamicin was undetected. In the combined group, effective concentrations of both gentamicin and metronidazole were detected. According to our results, the short-term preoperative oral medications combined with perioperative intravenous gentamicin and metronidazole prophylaxis appears to rational.
-
Thirty-one patients with delayed hemothorax were treated. The time from trauma to hemothorax formation ranged from 2 to 30 days. The patients with chest injuries accompanied by multiple rib fracture, potential vascular injuries and foreign body retention the thoracic cavity were observed closely. The diagnosis, pathogenesis and treatment were discussed.