Zhonghua wai ke za zhi [Chinese journal of surgery]
-
Zhonghua Wai Ke Za Zhi · Sep 1996
[The roles of Kupffer cell (KC) in reduction of post burn catabolism in early enteral feeding].
This study aimed to know the roles of Kupffer cells in post burn catabolism. Rats sustained with 30% III degrees flame burns of TBSA were divided randomly into early feeding (EF) group given gastroenteral feeding beginning from 2 hours postburn (n = 45), and delayed feeding (DF) group given the same nutritional solutions but starting on PBD3 (n = 45). Another 15 rats were served as normal controls (NS) without burning. ⋯ KCs may play one of the key roles in the "gut derived hypermetabolism". Early enteral feeding can enhance the barrier function of intestinal mucosa and prevent the translocation of endotoxin from gut to blood stream in some extent. Early enteral feeding can reduce catabolism via the modulation of hyperactivity of Kcs and the decrease of excessive secretion of catabolic hormones.