Ultrasound in medicine & biology
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Ultrasound Med Biol · Mar 2008
Peripheral therapeutic ultrasound stimulation alters the distribution of spinal C-fos immunoreactivity induced by early or late phase of inflammation.
The purpose of this investigation was to examine the central modulated effects of therapeutic ultrasound (US) on neuronal activity in the spinal cord on early and late phases of inflammation. In this study, induction of c-Fos protein, which reflects neuronal activation (particularly inflammatory nociception), was investigated in the lumbar spinal cord with immunohistochemistry. Inflammatory monoarthritis was induced in 20 male Wistar rats (weighing 250-300 g) via intra-articular injection of complete Freund's adjuvant (CFA) into the tibiotarsal joint. ⋯ In contrast, the US did not suppress, but rather enhanced, the number of c-Fos-LI neurons during the late inflammatory phase. The peripheral influences of US on the central modulation of the spinal nociceptive processing system is suggested and may reflect the work being done through the neuroplasticity of spinal cord in response to peripheral stimulation of US. Therefore, we propose a difference in spinal expression of c-Fos-LI neurons between effects of peripheral US stimulation in arthritic models that underlie early and late inflammatory pain. (E-mail: sherrie@sunrise.hk.edu.tw).