Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
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Zhejiang Da Xue Xue Bao Yi Xue Ban · Mar 2006
[COX-2 mediates U50488H-induced delayed cardioprotection in isolated rat heart].
To determine whether U50488H, a selective agonist of kappa-opioid receptor, could induce biphasic (early and late) cardioprotection against myocardial ischemia/reperfusion injury and to explore the underlying mechanisms. ⋯ The late (but not the early) phase of cardioprotection induced by kappa-opioid receptor agonist might be mediated by COX-2.