Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
-
Zhejiang Da Xue Xue Bao Yi Xue Ban · Sep 2010
Review[Research advances of inflammasome and its role in sepsis].
Inflammasomes are high-molecular-weight, multiprotein complexes in cells, which are assembled after cytoplasmic nucleotide-binding oligomerization domain like receptors (NLRs) sense pathogens and danger signals. The inflammasome can activate caspase-1, and later makes the pro-IL-1β, proIL-18 precursor mature by cleavaging, thereby mediates the innate immunity. Dysregulation of inflammasomes plays an important role in the development of sepsis and other immune inflammatory diseases, thus inflammasome may be a new target for prevention and treatment of sepsis.
-
Zhejiang Da Xue Xue Bao Yi Xue Ban · Sep 2010
[Early high-volume hemofiltration treatment in severe sepsis].
To evaluate the effect of early application of high-volume hemofiltration treatment (HVHF) on the levels of lactic acid, pro-inflammatory cytokines and C-reactive protein (CRP) in plasma, as well as APACHE II score in patients suffering from severe sepsis. ⋯ The early application of HVHF could clear the plasma lactic acid and pro-inflammatory cytokines, and improve the tissue oxygenation in severe sepsis.