Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
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Zhejiang Da Xue Xue Bao Yi Xue Ban · May 2016
[Advances of immunological pathogenesis research in HIV related neurocognitive disorder].
With extended life of HIV-infected patients due to highly active anti-retroviral therapy (HAART), the rate of HIV associated neurocognitive disorder (HAND) remains high and attracts much attention. The evidence is clear that cytokines are elevated in the blood of patients with HIV infection, which contribute to elevating the permeability of blood-brain barrier. ⋯ These activated brain glial cells and perivascular macrophages, which release inflammatory mediators, are the main contributors to neuroinflammation resulting in neuronal dysfunction. The pathogenesis of HAND is multifaceted, however, mounting evidence indicates that HIV related neuroinflammation plays a major role, which should be the focus of therapeutic research for HAND in future.