Acta neuropathologica
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Acta neuropathologica · Sep 2005
Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy.
Cerebral amyloid angiopathy (CAA) is defined by beta-amyloid peptide (Abeta) depositions in cerebral vessels and is associated with Alzheimer's disease (AD). The relationship between sporadic CAA and AD, and the origin of Abeta in CAA are poorly understood. The aim of our study was to investigate the relationship between CAA and AD. ⋯ In concordance with other studies, the severity of both AD pathology and CAA showed a low, but significant correlation. This correlation, however, was only caused by the significant increase of occipital CAA with increasing AD pathology (P<0.01), and was independent of APOE genotype. Our results suggest that progressing AD pathology not only increases the severity of CAA, but also shifts its topographical distribution towards the occipital cortex.
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Acta neuropathologica · Sep 2005
Editorial Biography Historical ArticleAnnouncing the winner of the 2005 Kurt Jellinger Prize.