American journal of diseases of children (1960)
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We treated two children with sickle cell disease and intracranial hemorrhage. The incidence of intracranial hemorrhage is increased in sickle cell disease, although not as markedly as that of cerebral infarction. ⋯ Children, however, are more likely to have subarachnoid hemorrhage without an identifiable aneurysm. We hypothesize that both hemorrhages and infarcts are due to large-vessel cerebral vasculopathy secondary to the abnormal rheologic features of sickled cells.