Nature and science of sleep
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Treatment-emergent central sleep apnea (TECSA), also called complex apnea, occurs in 5%-15% of sleep apnea patients during positive airway pressure (PAP) therapy, but the clinical predictors are not well understood. The goal of this study was to explore possible predictors in a clinical sleep laboratory cohort, which may highlight those at risk during clinical management. ⋯ Clinical predictors of treatment-evoked central apnea spanned demographic, medical history, sleep physiology, and titration factors. Improved predictive models may be increasingly important as diagnostic and therapeutic modalities move away from the laboratory setting, even as PSG remains the gold standard for characterizing primary central apnea and TECSA.
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To evaluate sex differences in predictors of obstructive sleep apnea (OSA) as per outcomes from home sleep apnea testing. ⋯ This study found that males and females report different symptoms upon clinical evaluation for suspected sleep apnea, with some of the "classic" OSA features to be more common in and robustly predictive for males. The finding that advancing age uniquely and robustly predicted OSA in females reinforces our understanding that age-related changes in sex hormones play a role in the development and/or manifestation of sleep disordered breathing. Need exists for sex-specific prediction models and quantification of menopausal status in OSA screening tools.