Curēus
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Objective The study's objective is to examine national trends in emergency department visits for unintentional fall-related fractures among children aged 0 to 19 years between 2001 and 2015. Methods The National Electronic Injury Surveillance System - All Injury Program was used to generate national estimates of fall-related fractures treated in emergency departments. Subsequently, according to demographic characteristics, body parts, and sport activities, age-adjusted fracture rates were calculated using the 2000 U. ⋯ The joinpoint regression program was used to examine the average annual percent change in fracture rates during the study period. Results An estimated 7.9 million emergency department visits for fall-related fractures among U. S. children occurred between 2001 and 2015. Overall, upper extremity fractures accounted for 70% of the cases. Trend analyses demonstrated that fracture rates markedly decreased among children aged 10 to 15 years by -2.5% (95% C: -3.4% to -1.6%) per year. After adjusting for age, boys' fracture rates decreased annually by -1.9% (95% CI: -3.1% to -0.6%), whereas the average decrease in girls was less accentuated by -1.4% (95% CI: -1.8% to -1.0%) per year. Notably, forearm/wrist fracture rates decreased annually by -2.4% (95% CI: -2.9% to -1.9%) from 2004 onwards. In contrast, head and neck fracture rates significantly increased on average by 2.6% (95% CI: 1.3% to 3.9%) per year. Conclusion Childhood emergency department visits for fall-related fractures significantly decreased in the U. S. between 2001 and 2015. However, further research is needed to determine factors related to upward trends in head/neck fractures seen during the study period.
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Aims To analyse the learning points from the first 30 days of the COVID-19 lockdown at our institution. Patients & methods Following ethical approval, data were collected prospectively on all patients admitted under orthopaedics between March 23, 2020, and April 22, 2020. This included baseline demographics (sex, age), biochemical (blood tests), radiological (chest X-ray (CXR), computed tomography (CT)), nature and mechanism of injury, comorbidities, regular medication, observations, specific respiratory symptoms of COVID-19, management, operations, time to theatre, and outcome including mortality incidence. ⋯ An early decision on escalation and resuscitation status in the emergency department improves patient flow significantly. Remote working was effective and could be extended in the future. We have highlighted the significant changes to expect should there be a second wave of the virus and effective solutions for managing the problems that arise, which could be useful for other units.
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Introduction Retraction of published papers has a far-reaching impact on the scientific world, especially if the retracted papers were published in high-impact journals. Although it has been noted that the retraction rates of journals correlated with their citation metrics, no conclusive data were available for most clinical specialties. In this study, we determined the retraction rate for anesthesia and two comparison groups (neurosurgery and high impact clinical journals). ⋯ However, the number of papers published in each journal and the absolute number of retractions showed a positive correlation with the citation metrics. The H-index showed stronger correlations with these parameters than the Impact factor. Conclusions The number of retractions increased in proportion to both the number of papers published in a journal and the citation metrics of that journal.
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The use of conventional therapeutic approaches in patients with lymphoma demonstrates significant drug resistance leading to poor prognosis with reduced median survival period. T-cell immunotherapy has diverted huge attention of the researchers in recent times to engage in the stated research studies in the pool of chemotherapy-refractory lymphoma patients. B-cell antigen CD19-targeted chimeric antigen receptor (CAR) T-cell products are approved for the treatment of non-Hodgkin B-cell refracting or relapsing lymphoma. ⋯ It is used in patients with non-Hodgkin B-cell refracting or relapsing lymphoma who had no response to prior therapeutic regiment involving the use of chemotherapeutics. Here, we review the mode of action, safety, and efficacy of Yescarta.
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A case of a 45-year-old male presentation with viral pneumonia with anemia and thrombocytopenia and was admitted to COVID-19 ICU. The blood bank encountered a discrepancy in blood grouping and cross-match, which were subsequently resolved. The patient presented to the emergency room with fever and shortness of breath. ⋯ Cold agglutinin titer at 4-degree Celsius was 64. The blood sample showed auto agglutination at collection and discrepancy in blood grouping and cross-matching, which were subsequently resolved. As observed in this case report, COVID-19 infection can be associated with cold agglutinin disease and Autoimmune hemolytic anemia, and cold agglutinins should be recognized as potentially significant due to interference with laboratory investigations and complications associated with COVID 19.