Curēus
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Case Reports
A Case of Severe Acute Pancreatitis Secondary to COVID-19 Infection in a 30-Year-Old Male Patient.
A 30-year-old male with no significant medical history presented to the emergency department with complaints of fever, two days of intermittent abdominal pain, dry cough, nausea, vomiting, four days of diarrhea, and worsening dyspnea. Initial evaluation revealed a fever of (102.5 F) and tachycardia (114/min) with hypoxia (SaO2: 84% on room air) and bilateral wheezing on lung auscultation. X-ray of the chest revealed bilateral and peripheral ground-glass and consolidative pulmonary opacities. ⋯ His COVID-19 test came positive, and he was admitted to the intensive-care unit. He was managed symptomatically, and improvement in his clinical condition was observed after three days of admission. This case highlights a possible association between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), abdominal pain secondary to acute pancreatitis, and the need for meticulous clinical evaluation in patients presenting with gastrointestinal complaints.
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Introduction Migraine is a frequent neurological condition manifested by several episodes of headache. Calcitonin gene-related peptide (CGRP) has been shown to play a key role in the pathophysiology of migraine. Galcanezumab is a monoclonal antibody that binds CGRP and inhibits its action, without affecting the CGRP receptor. ⋯ Conclusions Galcanezumab is clinically safe and efficient for the management of migraine, and the use of a higher dose increases its efficacy. Future research directions should be geared toward determining the optimal dose of galcanezumab in the management of patients with migraine. Moreover, head-to-head comparative studies between galcanezumab and other related anti-CGRP receptor monoclonal antibodies are warranted.
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Objective The study's objective is to examine national trends in emergency department visits for unintentional fall-related fractures among children aged 0 to 19 years between 2001 and 2015. Methods The National Electronic Injury Surveillance System - All Injury Program was used to generate national estimates of fall-related fractures treated in emergency departments. Subsequently, according to demographic characteristics, body parts, and sport activities, age-adjusted fracture rates were calculated using the 2000 U. ⋯ The joinpoint regression program was used to examine the average annual percent change in fracture rates during the study period. Results An estimated 7.9 million emergency department visits for fall-related fractures among U. S. children occurred between 2001 and 2015. Overall, upper extremity fractures accounted for 70% of the cases. Trend analyses demonstrated that fracture rates markedly decreased among children aged 10 to 15 years by -2.5% (95% C: -3.4% to -1.6%) per year. After adjusting for age, boys' fracture rates decreased annually by -1.9% (95% CI: -3.1% to -0.6%), whereas the average decrease in girls was less accentuated by -1.4% (95% CI: -1.8% to -1.0%) per year. Notably, forearm/wrist fracture rates decreased annually by -2.4% (95% CI: -2.9% to -1.9%) from 2004 onwards. In contrast, head and neck fracture rates significantly increased on average by 2.6% (95% CI: 1.3% to 3.9%) per year. Conclusion Childhood emergency department visits for fall-related fractures significantly decreased in the U. S. between 2001 and 2015. However, further research is needed to determine factors related to upward trends in head/neck fractures seen during the study period.
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Aims To analyse the learning points from the first 30 days of the COVID-19 lockdown at our institution. Patients & methods Following ethical approval, data were collected prospectively on all patients admitted under orthopaedics between March 23, 2020, and April 22, 2020. This included baseline demographics (sex, age), biochemical (blood tests), radiological (chest X-ray (CXR), computed tomography (CT)), nature and mechanism of injury, comorbidities, regular medication, observations, specific respiratory symptoms of COVID-19, management, operations, time to theatre, and outcome including mortality incidence. ⋯ An early decision on escalation and resuscitation status in the emergency department improves patient flow significantly. Remote working was effective and could be extended in the future. We have highlighted the significant changes to expect should there be a second wave of the virus and effective solutions for managing the problems that arise, which could be useful for other units.
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Introduction Retraction of published papers has a far-reaching impact on the scientific world, especially if the retracted papers were published in high-impact journals. Although it has been noted that the retraction rates of journals correlated with their citation metrics, no conclusive data were available for most clinical specialties. In this study, we determined the retraction rate for anesthesia and two comparison groups (neurosurgery and high impact clinical journals). ⋯ However, the number of papers published in each journal and the absolute number of retractions showed a positive correlation with the citation metrics. The H-index showed stronger correlations with these parameters than the Impact factor. Conclusions The number of retractions increased in proportion to both the number of papers published in a journal and the citation metrics of that journal.