Curēus
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Castleman disease is a lymphoproliferative disorder characterized by atypical lymph node hyperplasia and systemic symptoms; it can also affect the skin and blood counts. The condition is categorized by the extent of involvement (unicentric or multicentric) and the observed lymph node pathology (hyaline-vascular, plasma cell or mixed cellularity). Pathogenesis also has a role in the classification and treatment of multicentric Castleman disease; this variant can either be related to the presence of human herpesvirus-8 (HHV-8) infection or associated with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins and skin changes) syndrome, or idiopathic. ⋯ Her pulmonary symptoms and infiltrates on scan resolved after treatment with systemic levofloxacin, indicating that she had an antibiotic-sensitive afebrile pneumonia. We postulate that her siltuximab therapy blocked the IL-6-associated fever and constitutional symptoms that normally are a hallmark of pneumonia. Therefore, patients who are receiving medications such as siltuximab and tocilizumab that block the IL-6 pathway and impair the acute phase inflammatory response may fail to manifest constitutional symptoms such as fever when infected.
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The coronavirus disease 2019 (COVID-19) pandemic has impacted all aspects of our lives, including education and the economy, as we know it. Governments have issued stay-at-home directives, and as a result, colleges and universities have been shut down across the world. Hence, online classes have become a key component in the continuity of education. ⋯ Despite these challenges, most of the respondents (70.7%) believed that the COVID-19 pandemic has boosted their confidence in the effectiveness of online medical education. Consequently, 76% of participants intended to integrate the online expertise garnered during the pandemic into their practice. In short, the modern study demonstrated a largely positive impact of the COVID-19 pandemic on online medical education.
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Artificial Intelligence (AI) has taken radiology by storm, in particular, mammogram interpretation, and we have seen a recent surge in the number of publications on potential uses of AI in breast radiology. Breast cancer exerts a lot of burden on the National Health Service (NHS) and is the second most common cancer in the UK as of 2018. New cases of breast cancer have been on the rise in the past decade, while the survival rate has been improving. ⋯ Of course, AI has many applications and potential uses in radiology, but will it replace radiologists? We reviewed many articles on the use of AI in breast radiology to give future radiologists and radiologists full information on this topic. This article focuses on explaining the basic principles and terminology of AI in radiology, potential uses, and limitations of AI in radiology. We have also analysed articles and answered the question of whether AI will replace radiologists.
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Congenitally corrected transposition of the great arteries (CCTGA) is a rare congenital cardiac anomaly defined by atrio-ventricular and ventriculo-arterial discordance. This malformation makes up less than 1% of congenital heart defects. ⋯ This case highlights the association between such rare cardiac conditions. To the best of our knowledge, this is the first case of CCTGA at a young age, with the aforementioned abnormalities documented in the literature reported from Pakistan.
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Coronavirus disease 2019 (COVID-19) is an ongoing pandemic. COVID-19 leads to a plethora of clinical syndromes, most commonly affecting the pulmonary system but also the cardiovascular, hematologic, and gastrointestinal systems. There is emerging evidence of an association between COVID-19 and venous thromboembolism (VTE). ⋯ Anticoagulation was initiated per guidelines. There is a need to have a low threshold for suspecting pulmonary embolism in patients with COVID-19 infection who present with a sudden onset of severe hypoxia. There is a dire need to increase awareness among health care providers regarding this manifestation of the virus.