Japanese heart journal
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Japanese heart journal · Sep 2004
Use of recombinant activated factor VII in cardiac surgery for an effective treatment of severe intractable bleeding.
Experience gained with administration of supranormal-therapeutic doses (90 microg/kg) of recombinant activated factor VII in 7 cardiac surgery patients is presented. The patients were given recombinant activated factor VII postoperatively for intractable bleeding, 5 of them after surgical revision. ⋯ None of the patients needed reoperation. Administration of recombinant activated factor VII proved highly effective in management of massive hemorrhage in cardiac surgery.