Klinicheskaia meditsina
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Klinicheskaia meditsina · Nov 1992
Randomized Controlled Trial Comparative Study Clinical Trial[A comparative analysis of the antihypertensive activity of calcium antagonists and adrenoblockers in long-term treatment].
Essential hypertension stage II was treated by calcium antagonists, alpha- and beta-adrenoblockers in 362 patients. The drugs were compared for hypotensive efficiency at rest and exercise. ⋯ An increase in verapamil daily dose from 240 to 600 mg led to a rise in efficacy from 27 to 75% without an increase in the number of side effects. The antihypertensive effect of the drugs is shown to persist in long-term treatment as shown by exercise tests and static loads.