Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
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Tidsskr. Nor. Laegeforen. · Oct 1996
Case Reports[Analgesic effect of ketamine in a patient with neuropathic pain].
We report the effect of a single daily dose of ketamine in a 54 year old woman with fibromyalgia and severe post-traumatic neuropathic pain. A number of different approaches for pain relief had been tried with little effect. An intramuscular test dose of 0.4 mg/kg ketamine combined with 0.05 mg/kg midazolam lead to analgesia which lasted for almost two days. ⋯ This effect is distinctly different from the short-lasting (10-30 min) analgesic effect in cases of acute nociceptive pain. The long-term depression of the intensity of chronic pain states may be due to a reversal of NMDA receptor-dependent long-term potentiation of synapses in central pain pathways. By giving ketamine as a single dose at night the mental side-effects are reduced or avoided.
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Tidsskr. Nor. Laegeforen. · Oct 1996
Historical Article[What is anesthesia? Some reflections on the definition, measuring methods and mechanisms at the 150th anniversary].
Modern anaesthesia has developed over 150 years. In spite of this, we still do not know how to explain the state of anaesthesia exactly, how to measure anaesthesia nor what the basic mechanisms are. ⋯ Anaesthesia modulates or blocks the somatic and autonomic responses to injury, mainly by postsynaptic inhibition of impulses. Empirical dosing and clinical monitoring are still the rule, computerized and electronic systems need to be further refined.
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Tidsskr. Nor. Laegeforen. · Oct 1996
Historical Article[50 years with anesthesiologists in Norway].