British journal of plastic surgery
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Full thickness wounds, one on either side of the backs of rabbits, were covered with meshed or non-meshed split thickness skin grafts. The wounds were measured over a 3 month period and the minimum and maximum sizes of the wounds determined as well as the rate of growth. Wounds covered with meshed grafts contracted to 55% of the original size while those covered with non-meshed grafts contracted to 81.5% (p = less than 0.0001). The meshed wounds grew to 114.6% of original area and non-meshed grew to 153.3% (p = 0.035) after 13 weeks.
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The effects on anaesthesia of adding hyaluronidase to subcutaneous lignocaine were evaluated in a volunteer's forearm. Three beneficial effects were demonstrated: Onset of anaesthetic was immediate. ⋯ The area of anaesthesia was more than doubled compared to the control without hyaluronidase. The indications for the use of hyaluronidase in plastic surgery and its effectiveness as an adjunct to nerve blocks are discussed.