Alzheimer's research & therapy
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Alzheimers Res Ther · Jul 2016
Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease.
Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). ⋯ Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.
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Alzheimers Res Ther · Jul 2016
Comparative StudyBrain perfusion in dementia with Lewy bodies and Alzheimer's disease: an arterial spin labeling MRI study on prodromal and mild dementia stages.
We aimed to describe specific changes in brain perfusion in patients with dementia with Lewy bodies (DLB) at both the prodromal (also called mild cognitive impairment) and mild dementia stages, relative to patients with Alzheimer's disease (AD) and controls. ⋯ Our results are consistent with previous studies. We extend the scope of those studies by integrating prodromal DLB patients and by describing both hypo- and hyperperfusion in DLB. While decreases in perfusion may relate to functional impairments, increases might suggest a functional compensation of some brain areas.