Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk
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In this review we provide the definition, goals and objectives of neurocritical care, evaluation of brief history of its development. Mechanical ventilation, intracranial hypertension, neuromonitoring as underlying basics of neurocritical care approaches are discussed. ⋯ Research data of multiple organ disfunction syndrome in severe stroke are described. Further development of neurocritical care is being discussed.
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Vestn. Akad. Med. Nauk SSSR · Jan 2012
Review[Chronic pain: medico-biologic and sotsio-economic aspects].
In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels--from peripheral neuron to central structures--that provides pain perception and painful behaviour development.
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Vestn. Akad. Med. Nauk SSSR · Jan 2012
Review[Prevention of tuberculosis: current approaches to development of vaccines].
This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous "prime-boost" vaccination strategy against tuberculosis is discussed.
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Vestn. Akad. Med. Nauk SSSR · Jan 2012
Review[The application of nuclear medicine imaging in neurology, neurosurgery and psychiatry].
Analysis of use of nuclear medicine imaging (positron emission tomography and single photon emission computed tomography) in diagnosis, differential diagnosis and evaluation of treatment efficacy of central nervous system diseases is presented in this review. The possibility of radionuclide imaging techniques in different variants of dementia, Parkinson's disease, brain tumors is demonstrated on the basis of personal authors experience and recent literature data. Results of PET application in evaluating of the effecacy of stereotactic interventions in patients with anxiety obsessive disorders are also described in the review.