Journal of basic and clinical physiology and pharmacology
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J Basic Clin Physiol Pharmacol · Jan 2001
Changes in effective and lethal doses of intravenous anesthetics and lidocaine when used in combination in mice.
We studied the interactions between a local anesthetic agent, lidocaine, and two general anesthetic drugs, propofol and ketamine, in mice. We used two end points: hypnosis, reflected by loss of the righting reflex, and death. ⋯ Probit and isobolographic analyses revealed supra-additive (synergistic) interactions between lidocaine and each of the other anesthetic agents regarding both the effective dose and the lethal dose. No significant difference was found between propofol and ketamine regarding the supraadditive effect.