BMC pulmonary medicine
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BMC pulmonary medicine · Sep 2009
Randomized Controlled Trial Multicenter StudyEfficacy and safety of tigecycline versus levofloxacin for community-acquired pneumonia.
Tigecycline, an expanded broad-spectrum glycylcycline, exhibits in vitro activity against many common pathogens associated with community-acquired pneumonia (CAP), as well as penetration into lung tissues that suggests effectiveness in hospitalized CAP patients. The aim of the present study was to compare the efficacy and safety of intravenous (IV) tigecycline with IV levofloxacin in hospitalized adults with CAP. ⋯ These findings suggest that IV tigecycline is non-inferior to IV levofloxacin and is generally well-tolerated in the treatment of hospitalized adults with CAP.