BMC pulmonary medicine
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BMC pulmonary medicine · Feb 2020
Meta AnalysisEffect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis.
Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on the duration of mechanical ventilation remains unclear. The present study was conducted to review the extant literature in DEX and determine its influence on ventilation time in adult septic patients. ⋯ Administration of DEX for sedation in septic patients was not associated with the duration of mechanical ventilation, but it increased the ventilator-free days and reduced 28-day mortality.