Journal of medical case reports
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Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin. Despite being considered one of the main causes of metabolic acidosis, the association between an anion gap and MALA diagnosis is still uncertain. ⋯ In patients with MALA, there is a significant variability in the anion gap values, which is not related to the level of metformin accumulation, and therefore, it is doubtful whether measuring anion gaps is useful as an approach for MALA diagnosis.
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Review Case Reports
Effective treatment of osmotic demyelination syndrome with plasmapheresis: a case report and review of the literature.
Treatment options for chronic osmotic demyelination syndrome are limited to case reports and only a very few show complete recovery. We report a case of complete recovery of chronic osmotic demyelination syndrome with plasmapheresis. ⋯ Plasmapheresis can be considered as an effective treatment modality in chronic osmotic demyelination syndrome.