Vnitr̆ní lékar̆ství
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Vnitr̆ní lékar̆ství · Sep 2004
Review[Pathogenesis of the chronic obstructive pulmonary disease (COPD)].
An inflammation in the bronchial wall is usually present already in an early stage of the disease. An inflammatory infiltration cause predominantly mononuclear cells in the mucous membrane and neutrophiles in the phlegm produced by airways. Also eosinophiles can participate in the inflammation. ⋯ Chronic inflammation is a cause of remodeling and narrowing of small airways. Destruction of pulmonary parenchyma and the inflammation cause loss of alveolar connection with small airways and elastic pulmonary stress decreases. Two theories try to explain COPD--a theory of imbalance between proteinases and antiproteinases and a theory of oxidation stress.
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Vnitr̆ní lékar̆ství · Sep 2004
[Implication of the lung function tests in chronic obstructive pulmonary disease].
The authors summarize the methods of lung function tests with play important role in diagnosis and monitoring the patients with chronic obstructive pulmonary disease.