Vnitr̆ní lékar̆ství
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Vnitr̆ní lékar̆ství · Apr 2007
[Long-term experience with trerpostinil infusion treatment in patients with pulmonary arterial hypertension in the Czech Republic].
Pulmonary arterial hypertension (PAH) is a serious primary illness of the pulmonary arterioles, characterised by progressive precapillary pulmonary hypertension. The conventional therapy for this condition is so-called specific pharmacotherapy, which addresses the key mechanisms in the pathophysiology of the illness, making use of drugs from the prostanoid group, endothelin receptor antagonists and phosphodiesterase inhibitors. Treprostinil is a stable analogue of prostacyclin, which can be administered subcutaneously, intravenously or by inhalation. ⋯ Treprostinil improves symptoms and hemodynamics for PAH patients and reduces mortality.