Vnitr̆ní lékar̆ství
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Vnitr̆ní lékar̆ství · Jan 2014
Review[The emerging pathogenesis-based strategies for treating sepsis].
The cornerstones of therapy for sepsis and septic shock remain the prompt and adequate hemodynamic resuscitation, administration of antibiotics that target the pathogen, removal or drainage of an infected source and organ support. Despite adequate treatment and advanced life-support, the mortality remains high. ⋯ Fortunately, recent advances in our understanding of the sepsis pathophysiology revealed new pathogenic paradigms, and, thus, provided new exciting therapeutic concepts. In this review, we briefly discuss emerging pathogenesis-based strategies for treating severe sepsis and septic shock.
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Vnitr̆ní lékar̆ství · Jan 2014
[International guidelines for management of severe sepsis and septic shock 2012 - comment].
Sepsis is one of the leading and grossly under recognized cause of death in the world. If not recognized early and treated promptly, sepsis leads to septic shock, multiorgan failure and death. This article summarizes recently updated international guidelines for management of severe sepsis and septic shock.