Vnitr̆ní lékar̆ství
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Vnitr̆ní lékar̆ství · Jan 2014
Review[The emerging pathogenesis-based strategies for treating sepsis].
The cornerstones of therapy for sepsis and septic shock remain the prompt and adequate hemodynamic resuscitation, administration of antibiotics that target the pathogen, removal or drainage of an infected source and organ support. Despite adequate treatment and advanced life-support, the mortality remains high. ⋯ Fortunately, recent advances in our understanding of the sepsis pathophysiology revealed new pathogenic paradigms, and, thus, provided new exciting therapeutic concepts. In this review, we briefly discuss emerging pathogenesis-based strategies for treating severe sepsis and septic shock.
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Vnitr̆ní lékar̆ství · Jan 2014
[International guidelines for management of severe sepsis and septic shock 2012 - comment].
Sepsis is one of the leading and grossly under recognized cause of death in the world. If not recognized early and treated promptly, sepsis leads to septic shock, multiorgan failure and death. This article summarizes recently updated international guidelines for management of severe sepsis and septic shock.
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Vnitr̆ní lékar̆ství · Nov 2013
Multicenter Study Observational Study[Serious sepsis treatment in intensive care departments in the Czech Republic - EPOSS Project pilot results].
Severe sepsis is still associated with significant morbidity and mortality, which is however different, as well as its management, depending on the region. What is the situation in the Czech Republic and what is the character of patients with severe sepsis is currently not known. The aim of the project is to describe the processes of care, outcome and characteristics of patients with severe sepsis admitted to the intensive care department of the Czech Republic. ⋯ Introducing the project, which in its first stage obtained valuable and internationally comparable data about patients with severe sepsis admitted to the involved ICU in the Czech Republic.