Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo
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Monaldi Arch Chest Dis · Apr 1995
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialThe efficacy and safety of moguisteine in comparison with codeine phosphate in patients with chronic cough.
We conducted a multicentre, double-blind, parallel group study to compare the clinical efficacy of a new antitussive drug, moguisteine (100 mg t.i.d.), to that of a reference standard, codeine (15 and 30 mg, t.i.d.). Both drugs were given orally for a period of two days. A group of 119 patients (mean age 54 yrs; 61 females and 58 males) with chronic, dry or slightly productive cough, associated with various respiratory disorders (including chronic obstructive pulmonary disease, respiratory malignancies and pulmonary fibrosis) were enrolled at six participating centres. ⋯ Adverse events were observed in two patients on moguisteine, three on codeine 15 mg, and five on codeine 30 mg. No event was serious, but discontinuation of treatment was required in two patients on codeine 30 mg. The results of our study suggest that moguisteine 100 mg t.i.d. is safe, and seems to have an antitussive activity similar to that of codeine 15-30 mg t.i.d.
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Monaldi Arch Chest Dis · Apr 1995
Comparative StudyFlow-dependent properties of positive expiratory pressure devices.
Valves for positive expiratory pressure (PEP) can be characterized as threshold resistors, ideally providing pressure independent of the expiratory flow, or as flow-dependent resistors. The aim of the study was to evaluate the flow-dependence properties of PEP devices of the flow resistor type compared to threshold resistor devices. Pressures were measured on three different flow resistor valves: the PEP-mask, the Pari-PEP-System and the System 22-PEP with orifice diameters of 1.5-5.0 mm; and on three threshold resistors, the underwater seal, the Ambu Positive End-Expiratory Pressure (PEEP) valve and the Vital Signs PEEP valve with pressures of 0, 5, 10, 15 and 20 cmH2O. ⋯ The Ambu PEEP valves acted as threshold resistors at the lower flows, but showed flow-dependency at higher flows. The Vital Signs PEEP valves gave lower pressures and Ambu PEEP valves gave higher pressures compared with indicated values, whereas the underwater seal gave the intended pressure. In clinical use of PEP treatment the actual pressure should be measured to ensure the intended pressure, no matter which type of resistor is used.