Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo
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Monaldi Arch Chest Dis · Jul 2003
ReviewImpact of sleep on ventilation and gas exchange in chronic lung disease.
Sleep has many effects on breathing, all potentially adverse, ranging from the respiratory centre to the lower airways and chest wall. The overall effect is to diminish ventilation with consequent hypoxaemia and hypercapnia. ⋯ Patients with obstructive airway disease are particularly adversely affected during sleep with hypoventilation and reduced tidal volume, whereas patients with interstitial disease maintain overall ventilation although respiratory frequency falls. Sleep-related effects are most pronounced in rapid-eye-movement (REM) sleep and can have significant cardiovascular consequences including sleep-related cardiac arrhythmias and pulmonary hypertension and can also predispose to nocturnal death, particularly during acute exacerbations.