Biochimica et biophysica acta
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Biochim. Biophys. Acta · Mar 2013
Exhaled breath and fecal volatile organic biomarkers of chronic kidney disease.
While much is known about the effect of chronic kidney disease (CKD) on composition of body fluids little is known regarding its impact on the gases found in exhaled breath or produced by intestinal microbiome. We have recently shown significant changes in the composition of intestinal microbiome in humans and animals with CKD. This study tested the hypothesis that uremia-induced changes in cellular metabolism and intestinal microbiome may modify the volatile organic metabolites found in the exhaled breath or generated by intestinal flora. ⋯ Analysis of breath and bowel gases may provide useful biomarkers for detection and progression of CKD and its complications.