Biochimica et biophysica acta
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Biochim. Biophys. Acta · Jun 2014
Glutamate transporter type 3 regulates mouse hippocampal GluR1 trafficking.
Rapid trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) to the plasma membrane is considered a fundamental biological process for learning and memory. GluR1 is an AMPAR subunit. We have shown that mice with knockout of excitatory amino acid transporter type 3 (EAAT3), a neuronal glutamate transporter, have impaired learning and memory. The mechanisms for this impairment are not known and may be via regulation of AMPAR trafficking. ⋯ Our results provide initial evidence for the involvement of EAAT3 in the biochemical cascade of learning and memory.