Biochimica et biophysica acta
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Biochim. Biophys. Acta · Dec 2015
Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function.
Early social isolation stress (SIS) is associated with the occurrence of anxiety behaviors. It seems interaction between the nitrergic system and mitochondrial function plays a role in mediating the anxiety-like behaviors. In this study, we aimed to investigate the anxiolytic effects of tropisetron in animal model of SIS and we try to illustrate the possible role of nitrergic system and mitochondrial function. ⋯ Our results demonstrated tropisetron attenuated the anxiogenic effects of SIS by mitigation of the negative effects of nitric oxide on mitochondrial function.