The journal of allergy and clinical immunology. In practice
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J Allergy Clin Immunol Pract · Nov 2018
Exacerbations in Adults with Asthma: A Systematic Review and External Validation of Prediction Models.
Several prediction models assessing future risk of exacerbations in adult patients with asthma have been published. Applicability of these models is uncertain because their predictive performance has often not been assessed beyond the population in which they were derived. ⋯ The preservation of 3 predictors in models derived from variable populations and the fairly consistent predictive properties of most models in 2 distinct validation populations suggest the feasibility of a generalizable model predicting severe exacerbations. Nevertheless, improvement of the models is warranted because predictive performances are below the desired level.