Annales pharmaceutiques françaises
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The aim of this study was to determine the stability of ready-to-use temsirolimus infusion solutions under different storage conditions. Solutions were prepared in polypropylene containers by adding temsirolimus injection to 0.9% sodium chloride infusion to reach a final concentration of 100mg/L. The following storage conditions were tested: (i) 4(o)C in the refrigerator; (ii) 20(o)C under room light exposure and light protection; and (iii) outdoor temperature with sunlight exposure. ⋯ Under daylight exposure, a substantial decrease in drug concentration was observed; after 1h, losses were higher than 10%. Exposed to UV light, half of the drug was lost after 45 min. In conclusion, temsirolimus 100mg/L in infusion polypropylene bags containing 0.9% sodium chloride was chemically stable when protected from light for 4 and 3 days at 4 and 20(o)C, respectively.