The Journal of infectious diseases
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Randomized Controlled Trial
Accelerated hepatitis B vaccination schedule among drug users: a randomized controlled trial.
Hepatitis B vaccine provides a model for improving uptake and completion of multidose vaccinations in the drug-using community. ⋯ The accelerated vaccination schedule improves hepatitis B vaccination adherence among IDUs.
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Clinical Trial
Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa.
Antibiotic combination therapy might be more efficient than single antibiotics to combat Pseudomonas aeruginosa biofilms in the airways of patients with cystic fibrosis. We tested the ability of colistin sulphate-tobramycin combinations and single antibiotics to kill P. aeruginosa biofilms. ⋯ Colistin-tobramycin combinations are more efficient than respective single antibiotics for killing P. aeruginosa in biofilms in vitro, and they significantly reduced P. aeruginosa cell counts in a rat lung infection model and in patients with cystic fibrosis.