Advances in neurology
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Advances in neurology · Jan 1990
Comparative StudySpinal cord edema and changes in tissue content of Na+, K+, and Mg2+ after impact trauma in rats.
Changes in the tissue content of water, Na+, K+, and Mg2+ were measured in spinal cord samples from anesthetized rats subjected to impact trauma (T9 spinal segment) of varying severity: 25 g-cm (low injury), 100 g-cm (high injury). Laminectomized animals served as controls. Rats with high injury were killed at 15 min, 60 min, 4 hr, 24 hr, 3 days, or 7 days after trauma. ⋯ Whereas changes in the tissue content of water, Na+, and K+ occurred at 24 hr regardless of the injury severity, changes in total Mg2+ were correlated with the degree of injury. These data are consistent with the conclusion that edema formation (and associated Na+ and K+ changes) after spinal cord trauma may be an epiphenomenon and does not significantly contribute to injury progression. In contrast, reductions in Mg2+ content may represent an important factor in the development of irreversible tissue damage.
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Advances in neurology · Jan 1987
Comparative Study Clinical Trial Controlled Clinical TrialBromocriptine in the treatment of Parkinson's disease: a double-blind study against L-dopa/carbidopa.