Yonsei medical journal
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Yonsei medical journal · Sep 2018
Randomized Controlled TrialEffects of Early Exercise Rehabilitation on Functional Recovery in Patients with Severe Sepsis.
Severe sepsis is associated with functional disability among patients surviving an acute phase of infection. Efforts to improve functional impairment are important. We assessed the effects of early exercise rehabilitation on functional outcomes in patients with severe sepsis. ⋯ Early physical rehabilitation may improve functional recovery at hospital discharge, especially in patients with high initial severity scores.
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Yonsei medical journal · Sep 2018
ReviewGeneration, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells.
Dendritic cells (DCs) play a key role not only in the initiation of primary immune responses, but also in the development and maintenance of immune tolerance. Numerous protocols have been developed to generate tolerogenic DCs (tolDCs) ex vivo, and the therapeutic efficacy of ex vivo-generated tolDCs has been demonstrated in autoimmune disease animal models. Based on successes in small animal models, several clinical trials have been completed or are on-going in patients with autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, and Crohn's disease. ⋯ S. National Institutes of Health. Although the number of tolDC-based clinical trials is much smaller than the hundreds of clinical trials using immunogenic DCs, tolDC-based treatment of autoimmune diseases is becoming a reality, and could serve as an innovative cellular therapy in the future.
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Yonsei medical journal · Sep 2018
High-Carbohydrate Diets and Food Patterns and Their Associations with Metabolic Disease in the Korean Population.
Although an Asian diet is typically high in carbohydrate and low in fat, there has been a steady increase in the rate of cardiometabolic disease in Asian countries over the past decade. We evaluated food patterns of a high-carbohydrate diet and examined their associations with metabolic disease. ⋯ This study suggests that a very-high-carbohydrate diet for the Korean population is attributable to lower consumption of MFEB and dairy products and is associated with several metabolic risk factors. The appropriate distribution of macronutrients for the prevention and management of metabolic disease should be explored.