Zeitschrift für Rheumatologie
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To date, the long-term course of fibromyalgia (FM) generally shows little improvement and many patients have problems managing their private, social and professional lives, if at all. Health workers in various specialties, and even in the same specialty, have differing concepts on etiology, diagnosis and treatment of FM. In its work spanning 2 years, an interdisciplinary working group made up from 10 scientific associations reviewed the literature and developed an S3-level consensus guideline. ⋯ A stepwise treatment approach with patient education, endurance training, multi-modal therapy and promotion of significant resources is recommended. Of the psychotherapeutic methods, cognitive behavioural training has proved the most relevant. Only a handful of drug therapies have undergone controlled trials, most however only over a period of a few weeks.
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Muscle and nerve biopsies provide valuable information contributing to the diagnosis of diseases of the peripheral nervous system and skeletal muscle. The application of modern histological, immunohistochemical, electron microscopic and molecular methods establishes a definite diagnosis in many cases and narrows the spectrum of possible entities in most of the remaining cases. Inflammatory myopathies and neuropathies are distinguished from non-inflammatory muscular and peripheral nervous conditions. The latter include muscular dystrophies and congenital myopathies, hereditary neuropathies, metabolic diseases affecting skeletal muscle and peripheral nerves as well as degenerative myopathies and neuropathies including sporadic motor neuron diseases.