Computers and biomedical research, an international journal
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A simulator of general anesthesia is described. It consists of an integrated set of physiologic computer models and a graphics display. The model predicts many of the physiologic and pharmacodynamic changes associated with general anesthesia. ⋯ Both intravenous and inhalation agents are included. Examples of its capabilities are presented, including pharmacokinetic changes associated with thiopental administration to a hypovolemic subject, administration of oxygen in several pulmonary pathologic conditions, and a simulation of an induction using fentanyl or thiopental. The model, combined with the graphics interface, becomes a real-time simulator useful for training students and residents.