Bulletin du cancer
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Geriatric oncology represents a novel specialty which can be defined as specific older cancer patients management. It includes a validated geriatric procedure, the comprehensive geriatric assessment, which is the best way of approaching the complex interacting medical problems of frail older patients. ⋯ Geriatric assessment may provide either guidelines for anti-cancer treatment in the elderly, or guidelines for the management of older patients with cancer. Two clinical research ways are now developed : firstly the definition of the most relevant geriatric variables allowing clinical trials in such a heterogeneous population; secondly, the determination and the validation of a specific tool to screen frail and vulnerable older patients, and the study of the geriatric assessment impact on the quality of life of older cancer people.
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Gastrointestinal stromal tumors (GIST) are rare tumors occuring at all levels of the gastrointestinal tract, whose estimated incidence may be close to 2 new cases per 100 000 persons per year. GIST derive from the interstital cells of Cajal (ICC) responsible for the motility of the GI tract, or from a common precursor of ICC and of the smooth muscle cells of the digestive tract. GIST cells express the c-kit protoconcogene under an activated form, either mutated or constitutively activated, as well as the CD34 Ag. ⋯ Resistance are now being observed however. GIST has become the first model of a solid tumor treated efficiently by a treatment targetting the initial genetic alteration of the disease. Numerous question regarding the integration of this treatment with surgery and the long term outcome of these patients still remain to be answered however.