Archives of general psychiatry
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Arch. Gen. Psychiatry · Jan 2008
Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms.
Depressed mood is frequently reported by individuals who have sustained cerebral concussion but little is known about the nature of this alteration in mood state. ⋯ The results suggest that depressed mood following a concussion may reflect an underlying pathophysiology consistent with a limbic-frontal model of depression. Given that depression is associated with considerable functional disability, this finding has important clinical implications for the management of individuals with a cerebral concussion.