Archives of general psychiatry
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Arch. Gen. Psychiatry · Oct 2009
Randomized Controlled Trial Multicenter StudyIncremental benefit and cost of telephone care management and telephone psychotherapy for depression in primary care.
Effectiveness of organized depression care programs is well established, but dissemination will depend on the balance of benefits and costs. ⋯ Compared with current primary care practice, a structured telephone program including care management and cognitive behavioral psychotherapy has significant clinical benefit with only a modest increase in health services cost.
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Arch. Gen. Psychiatry · Oct 2009
Comparative StudyPositron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans.
The endogenous opioid system and opioid mu receptors (mu-receptors) are known to interface environmental events, positive (eg, relevant emotional stimuli) and negative (eg, stressors), with pertinent behavioral responses and to regulate motivated behavior. ⋯ Individual differences in the function of the endogenous mu-receptor system predict personality traits that confer vulnerability to or resiliency against risky behaviors such as the predisposition to develop substance use disorders. These personality traits are also implicated in psychopathological states (eg, personality disorders) in which variations in the function of this neurotransmitter system also may play a role.