Archives of general psychiatry

The most recent articles from: Arch. Gen. Psychiatry April 2010

Arch. Gen. Psychiatry · Apr 2010

Multicenter Study

Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.

The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment. ⋯ These data indicate that a genetic variant within the CRHBP locus affects response to citalopram in African American and Hispanic patients, suggesting a role for this gene and for the CRF system in antidepressant treatment response.

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