Archives of general psychiatry
-
Arch. Gen. Psychiatry · Feb 2012
Randomized Controlled TrialPrevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study.
Preventing posttraumatic stress disorder (PTSD) is a pressing public health need. ⋯ Prolonged exposure, CT, and delayed PE effectively prevent chronic PTSD in recent survivors. The lack of improvement from treatment with escitalopram requires further evaluation. Trauma-focused clinical interventions have no added benefit to survivors with subthreshold PTSD symptoms. Trial Registration clinicaltrials.gov Identifier: NCT00146900.
-
Arch. Gen. Psychiatry · Feb 2012
Clinical TrialSubcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression.
Deep brain stimulation (DBS) may be an effective intervention for treatment-resistant depression (TRD), but available data are limited. ⋯ The findings of this study support the long-term safety and antidepressant efficacy of subcallosal cingulate DBS for TRD and suggest equivalent safety and efficacy for TRD in patients with BP. Trial Registration clinicaltrials.gov Identifier: NCT00367003.