Thorax
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Neutrophils may cause tissue disruption during migration and by releasing cytotoxic molecules. However, the benefits of neutrophil depletion observed in experimental models of lung injury do not correspond with the poor outcome of neutropenic patients. ⋯ Release of MMP-9 from neutrophils is required for adequate matrix processing and lung repair.
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Randomized Controlled Trial Multicenter Study Comparative Study
Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome.
Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. ⋯ In patients with OHS, medium-term treatment with NIV is more effective than CPAP and lifestyle modification in improving pulmonary hypertension, left ventricular hypertrophy and functional outcomes. Long-term studies are needed to confirm these results.