Thorax
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Randomized Controlled Trial
Stability of ARDS subphenotypes over time in two randomised controlled trials.
Two distinct acute respiratory distress syndrome (ARDS) subphenotypes have been identified using data obtained at time of enrolment in clinical trials; it remains unknown if these subphenotypes are durable over time. ⋯ ARDS subphenotypes are largely stable over the first 3 days of enrolment in two ARDS Network trials, suggesting that subphenotype identification may be feasible in the context of clinical trials.
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Multicenter Study
Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years.
Cigarette smoking is the strongest risk factor for COPD. Smoking burden is frequently measured in pack-years, but the relative contribution of cigarettes smoked per day versus duration towards the development of structural lung disease, airflow obstruction and functional outcomes is not known. ⋯ Smoking duration alone provides stronger risk estimates of COPD than the composite index of pack-years.
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Multicenter Study Observational Study
Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis.
Antibiotic treatment for pulmonary symptoms in preschool children with cystic fibrosis (CF) varies among clinicians. The lung clearance index (LCI) is sensitive to early CF lung disease, but its utility to monitor pulmonary exacerbations in young children has not been assessed. ⋯ LCI significantly deteriorated with pulmonary symptoms relative to baseline and improved with antibiotic treatment. These data suggest that LCI may have a role in the routine clinical care of preschool children with CF.