Arkhiv patologii
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Examinations of 43 section observations of shock established that the role of the syndrome of disseminated intravascular blood coagulation (DIBC) in the development of shock was variable: in some cases it caused the shock condition (embolism with amniotic waters, premature desquamation of the placenta), in others it is its consequence (hemorrhagic, cardiogenic shock). Morphogenesis of the DIBC syndrome is different depending on its role in the development of the shock condition. ⋯ The characteristic morphological features of DIBC as the consequence of the shock include incomplete thrombus formation processes with the presence of pre-thrombi and/or strands and filaments of fibrin, involvement of the adrenals, the presence of the phenomenon of fibrin lining of vascular walls. The time of development of intravascular coagulation does not coincide with shock occurrence and may be different in various parts of the microcirculatory bed.
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The main principles of quantitative morphology allowing an objective study of chronopathology are presented. Three main types of chronopathology associated with changes in the rate of development, dyschronization, and dyscyclicity of pathomorphological processes are considered. Mathematical models of the main types of chronopathology are presented.