Arkhiv patologii
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[The significance of epidermal changes in the early diagnosis and development of mycosis fungoides].
In 47 patients with stage I mycosis fungoides, biopsy of skin has revealed substantial changes in epidermis acanthosis with confluent epidermal processes, focal dystrophy of basal cells, mitoses in various epidermal layers, parakeratotic foci without a granular layer. Histoautoradiographic and immunomorphological studies demonstrated that enhanced proliferative activity of keratinocytes that was more pronounced in stages I and II mycosis fungoides and impaired epidermal differentiation that was predominant in neoplastic stage III underlay the above changes. There was ultrastructural evidence for abnormal epidermal keratinization. It was proposed that epidermal abnormalities made an important contribution to the development of mycosis fungoides.
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A case of the shock lung with numerous hyalin membranes is described in a 19-year-old woman after the delivery with a consequent acute respiratory failure. Bacterial shock, acute respiratory disease, possible embolism with amniotic fluid in combination with hypercoagulation typical for pregnancy are named among the causes of the shock lung development. A partial resolution and marked organization of the hyalin membranes are observed.