Arkhiv patologii
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[The significance of epidermal changes in the early diagnosis and development of mycosis fungoides].
In 47 patients with stage I mycosis fungoides, biopsy of skin has revealed substantial changes in epidermis acanthosis with confluent epidermal processes, focal dystrophy of basal cells, mitoses in various epidermal layers, parakeratotic foci without a granular layer. Histoautoradiographic and immunomorphological studies demonstrated that enhanced proliferative activity of keratinocytes that was more pronounced in stages I and II mycosis fungoides and impaired epidermal differentiation that was predominant in neoplastic stage III underlay the above changes. There was ultrastructural evidence for abnormal epidermal keratinization. It was proposed that epidermal abnormalities made an important contribution to the development of mycosis fungoides.
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A case of the shock lung with numerous hyalin membranes is described in a 19-year-old woman after the delivery with a consequent acute respiratory failure. Bacterial shock, acute respiratory disease, possible embolism with amniotic fluid in combination with hypercoagulation typical for pregnancy are named among the causes of the shock lung development. A partial resolution and marked organization of the hyalin membranes are observed.
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Basing on 18 observations, histological features of malignant melanomas on the soles and the terminal phalanges of the toes were revealed and described in detail. A specific character of melanomas with such localization is evident from the histological pattern and clinical manifestations. It is suggested to distinguish the described acral lentiginous melanoma as a separate clinico-morphologic form of melanoma.
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The analysis of 7 cases of subacute spongiform encephalopathy, the Creutzfeldt-Jacob disease (CJD), is given. Three main morphological features are typical for this disease: spongiform change of the grey matter, progressive neuronal loss and proliferation of the astroglia cells. ⋯ As a rule, the disease affects at first the cortex of the cerebral hemispheres, then subcortical nuclear groups, cerebellum and more rarely nuclear groups of the brain stem. The demyelinization of the white matter of the cerebral hemispheres is not obligatory for the CJD and appears in cases with a severe lesion of the grey matter.
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Case Reports
[Pathological anatomy of the myorenal syndrome in the light of current methods of treatment].
Clinical and morphologic analysis of material from 39 patients who died from the myorenal syndrome is given. It is shown that during last 10 years the mortality rate from this syndrome is markedly reduced from 55 to 14% due to new active methods of detoxication. ⋯ It is noted also that progress in the treatment changed the whole structure of mortality, and the role of new complications, mainly septicemia, was increased. The sources of septicemia are both skin and muscles lesions and catheters and shunts used in modern methods of treatment.