Oral surgery, oral medicine, and oral pathology
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Oral Surg. Oral Med. Oral Pathol. · Jun 1992
Randomized Controlled Trial Clinical TrialEfficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation.
The goal of reducing oral complications during chemotherapy and bone marrow transplantation has received attention at several centers. The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection. The results of this study did not show a reduction in mucositis with the use of these rinses. However, potential bacterial and fungal pathogens were identified less frequently in the patients using chlorhexidine rinse.
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Oral Surg. Oral Med. Oral Pathol. · Jun 1992
Histopathology of smokeless tobacco lesions in professional baseball players. Associations with different types of tobacco.
We examined 142 biopsy specimens of smokeless tobacco-associated oral mucosal lesions from 133 professional baseball players. Four types of epithelial change were observed in the specimens: hyperparakeratosis, hyperorthokeratosis, pale surface staining, and basal cell hyperplasia. ⋯ The thickness of hyperkeratosis in a specimen correlated directly with the amount of smokeless tobacco use. The use of snuff was more frequently associated with development of oral mucosal lesions than was the use of chewing tobacco, and snuff appeared to cause a greater variety and severity of epithelial change than did chewing tobacco.