The Tohoku journal of experimental medicine
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Tohoku J. Exp. Med. · Dec 2024
Expression of Vascular and Tissue Repair Factors in Laryngeal Granulomas.
Voice abuse, chronic cough, laryngeal surgery, and tracheal intubation may lead to injury and subsequent repair/remodeling in the vocal fold mucosa. Periostin is known to be involved in airway remodeling and is also associated with various otolaryngological diseases. D-β-aspartic acid is the major isomer of D-aspartic acid found in tissues of elderly individuals. ⋯ The expression of periostin and D-β-aspartic acid was also observed in the specimens. CD31-positive cells (endothelial cells) and CD34-positive cells (progenitors of endothelial cells) were observed in the specimens. Our results indicate that the overexpression of CD31, CD34, D-β-aspartic acid, and periostin may play a role in the pathogenesis of laryngeal granulation tissue, and we speculate that D-β-aspartic acid and periostin could serve as novel biomarkers and therapeutic targets for laryngeal granulation tissue.
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Tohoku J. Exp. Med. · Dec 2024
Plasma Leucine-Rich Alpha-2-Glycoprotein 1 Reflects Higher Histological Grade, Worse Disease-Free Survival, and Unfavorable Overall Survival in Colorectal Cancer Patients who Receive Tumor Resection.
Leucine-rich alpha-2-glycoprotein 1 (LRG1) promotes colorectal cancer (CRC) growth, migration, and invasion. This study intended to investigate the association of plasma LRG1 with clinical characteristics, disease-free survival (DFS), and overall survival (OS) in CRC patients who received tumor resection. This study retrospectively included 125 CRC patients who received tumor resection. ⋯ Furthermore, plasma LRG1 ≥ 100 μg/mL (hazard ratio (HR): 2.728, P = 0.036) and age ≥ 60 years (HR: 2.815, P = 0.041) were independently associated with shortened DFS. Only node stage (HR: 3.150, P = 0.004) was independently linked with shortened OS. In conclusion, LRG1 is associated with elevated histological grade and worse DFS and OS, with its level ≥ 100 μg/mL as an independent factor for shortened DFS in CRC patients who receive tumor resection.